Stage-Specific Nuclear Expression of NF-κB in Mammalian Testis
نویسندگان
چکیده
منابع مشابه
Stage-Specific Nuclear Expression of NF-kB in Mammalian Testis
The Rel/nuclear factor (NF)-kB family of transcription factors are important intracellular conveyors of extracellular signals in a number of systems. However, little is known of their roles in the specialized, hormonally regulated environment of the mammalian testis. In this study NF-kB p50 and p65 proteins were found to be constitutively present and active in the nucleus of Sertoli cells cultu...
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Background & objectives: Nuclear Factor kappa B (NF-κB), a master switch transcription factor, plays a critical role in the progression and development of hyperglycemia-induced microangiopathy. Hyperglycemia activates NF-κB, and subsequently increases pro-inflammatory cytokines such as TNF-α, IL-6 and IL-1β leading to development of inflammation. Some new studies have revealed the involvement o...
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The nuclear factor-kappaB (NF-kappaB) family of transcription factors regulates the expression of a variety of genes involved in apoptosis and immune response. We examined relationships between genotypes at five NF-kappaB subunits (NFKB1, NFKB2, REL, RELA, and RELB) and variable expression levels of 15 NF-kappaB regulated proteins with heritability greater than 0.40: BCL2A1, BIRC2, CD40, CD44, ...
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ژورنال
عنوان ژورنال: Molecular Endocrinology
سال: 1998
ISSN: 0888-8809,1944-9917
DOI: 10.1210/mend.12.11.0194